Two different types of cartilage inside the knee, A hard hat, particular hyaline cartilage and bone, joint, muscle, and the tight ends hard. In the form of two semicircular pieces of cartilage, and Menisci of fibro cartilage, a bit lighter on each side.
OA is primarily a disease of the hyaline cartilage. Hyaline cartilage proteoglycans (complexes of proteins and sugars) and chondrocytes and matrix composition. This Chondrocytes, ... A picture of the team, grape gelatin mold. There are grape gelatin matrix and chondrocytes. Cartilage cells, Chondrocytes, Matrix product is a normal healthy state. Responsible for developing the team.
However, OA, change in the development of hyaline cartilage metabolism. Chondrocytes in the cartilage destructive enzymes that create cracks and fissures begin to describe. "Fibrillations." Mentioned in
A perplexing question, "What a pain in knee OA?", The cartilage has no blood vessels or nerves. Therefore, the pain of osteoarthritis of the interest rate policy.
The number of potential suspects. For example, osteophytes (a bone) growth in the periosteum (a thin layer of bone) can lift. Nerve fibers, and a great source of pain when the periosteum.
To the bone and OA, in theory, the expansion of blood vessels in cartilage, bone pain and stress are associated with cause pain.
The joint (synovium) by OA inflamed it. Pain fibers in the joint capsule, and the inflammatory process, they are burning.
Joint capsule, the capsule irritability, loss of contracts, or nerve fibers.
By the same token, the pain fibers, Re-focus, a general, a liquid produced by the joint capsule expands.
Inside fibrocartilage of the knee, his front, there are two small pieces. Fibrocartilage (menisci) pieces and a rich supply of blood and nerve, joint, must be adhered to there. OA menisci are generally strong. This pain can cause a major cell attachment.
Muscle tension and pain can occur around the knee.
Finally, an increasing interest in the central nervous system of the brain - may cause pain in knee OA. , Cymbalta, a drug originally developed to treat depression, such drugs can be used to display the result, but more recent studies, OA pain was the symptom that led to FDA approval in 2011 patients have shown benefits.
